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Identification of actionable targets for breast cancer intervention using a diversity outbred mouse model

April 2023

– Caris Life Sciences

HER2/Neu-expressing diversity outbred F1 mice enable genetic linkage analysis
26 Genes in 3 quantitative trait loci (QTL) predicted breast cancer survival
The myeloid checkpoint gene, LILRB4, emerged as an actionable intervention target
TIEG1 suppresses tumor growth and is critical to regulatory T cell development

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