MI Profile
Comprehensive profiling that assesses DNA, RNA and proteins from tumor tissue to reveal a more complete picture to help tailor treatment plans for patients with solid tumor cancers
6-9 days
Average testing turnaround time upon specimen receipt
23,000+ genes
Simultaneously analyzed using Whole Exome Sequencing (WES) + Whole Transcriptome Sequencing (WTS)
25+ tumor-relevant protein biomarkers
Available globally
*Excluding USA, EEA, EU, CH countries
What it is:
MI Profile® tests include next-generation sequencing (NGS), immunohistochemistry (IHC), chromogenic in situ hybridization (CISH), pyrosequencing and AI-predictive algorithms for select tumor types.
Why it matters:
The result is a complete molecular blueprint that helps guide precise and individualized treatment decisions.

TESTING WORKFLOW
How MI Profile Works

Tumor Tissue Collected
A tissue sample is collected during a biopsy or surgical removal of your tumor.

DNA and RNA Sequencing Performed
Simultaneous WES/WTS delivers a more complete picture of the biomarkers driving your cancer.

Genomic Alterations Identified
Advanced bioinformatics identifies clinically relevant genomic alterations and molecular signatures from DNA and RNA sequencing data.

Clinical Report Delivered
Results are delivered to the ordering physician within 6-9 days of specimen receipt, providing molecular insights to help personalize treatment based on your cancer.
Test results
Complete Molecular Intelligence® Report
The Caris Molecular Profiling Report delivers high-impact results, including potentially relevant, actionable clinical information, in an easy-to-interpret format. Every report includes access to the Caris+®Portal and the Clinical Trials Connector™, which matches each patient’s unique biomarker expression profile to open, pertinent clinical trial opportunities.
Actionable Insights from Tissue
- Whole Exome Sequencing (WES – DNA), 23,000+ genes
- Whole Transcriptome Sequencing (WTS – RNA), 23,000+ genes
- Immunohistochemistry (IHC), 25+ tumor-expressed proteins

Specimen Requirements
Sample and Laboratory Specifications
Specimen Type
FFPE Tumor Tissue
Minimum Input
≥25 ng DNA from extracted tumor nucleic acid
Variant Coverage
- SNVs
- InDels
- CNAs
- Genomic Signatures: MSI, TMB
AI Signatures
Caris GPSai® for CUP cases and Caris FOLFIRSTai® for mCRC cases
Document Downloads
For international orders, email the completed
form to InternationalSupport@CarisLS.com, or
fax to 00 41 21 533 53 01.
*Excluding USA, EEA, EU, CH countries.
Next Steps
MI Profile

