Background:
- The WNT/beta catenin (CTNNB1) pathway plays an integral role in the development of HCC.•CTNNB1 has been implicated in HCC progression, metastasis, and drug resistance.
- The impact of CTNNB1 alterations on prognosis and efficacy of immunotherapy and tyrosine kinase inhibitors in HCC is unclear.
- We examined associations between CTNNB1 mutations and mRNA expression and clinical outcomes in a real-world cohort of patients with HCC.