The Caris Life Sciences Observational Studies initiative is a collection of multicenter, prospective and observational outcomes tracking studies designed to collect data on the demographics, presentation, diagnosis, treatment, resource use, and outcomes of eligible patients who previously have undergone Caris Molecular Intelligence tumor profiling for treatment of solid tumor cancer. Participation guidelines and study protocols have been reviewed and approved by an independent Institutional Review Board. The information collected by the Observational Studies initiative includes detailed molecular profiling information about a participating patient’s disease, treatment plan, and response. This information represents statistically correlated data to inform physicians about the efficacy of various chemotherapies and biological therapies. The data is intended to demonstrate the clinical utility of tumor profiling and to assist physicians in the delivery of precision medicine to their patients